Thursday, June 5, 2025

LNPs in covid injections lead to slow, systemic toxicity and long-term damage

LNPs in covid injections lead to slow, systemic toxicity and long-term damage

By Rhoda Wilson

Posted on June 5, 2025




Lipid nanoparticles (“LNPs”) are very small spherical particles composed of lipids, serving as a pharmaceutical drug delivery system. In mRNA covid vaccines,” for example, LNPs act as delivery vehicles that protect the mRNA and transport it to the right place within cells.

The exact number of LNPs in a single dose of Pfizer-BioNTech’s or Moderna’s covid injection is unknown.  Moderna has responded that it is “irrelevant” and the UK’s drug regulator hasn’t provided an answer.

The use of these LNPs may lead to slow, systemic toxicity, including inflammation, metabolic dysfunction and potential long-term damage, such as neurodegenerative or autoimmune triggers.

“Billions of people have been injected with a poorly characterised chemical delivery system – and now we’re just starting to see the fallout,” World Council of Health says.

Lipid nanoparticle containing mRNA Does this look like a virus albeit man made


This is a modified, as very technical, translation of a Substack post by Genervter Bürger. Thank you to Genervter Bürger and Maria Gutschi for this important summary, see HERE.

The Mystery No One Wants to Solve

Let’s start with a simple question: How many lipid nanoparticles (“LNPs”) are in a single dose of Pfizer’s BNT162b2 or Moderna’s mRNA-1273 vaccine?

You’d think this would be basic information. But when researcher Maria Gutschi went digging, the answers were unsettling.

  • Moderna’s response to a Freedom of Information Act request? “We don’t know, and it’s irrelevant.”
  • The MHRA (UK’s drug regulator)? Crickets.

The only study we could find detected SM-102 (Moderna’s ionisable lipid) lingering in blood days after injection – still above background levels at Day 7 (0.12 ng/ml).

“Background levels”? For a synthetic, non-human lipid? That’s like saying a tiny bit of arsenic in your coffee is normal.

The Dirty Secret: Oxidation and Contamination

Now, let’s talk about ALC-0315 (Pfizer’s LNP lipid). A structural analysis found:

  • 0.19% oxidised impurities in fresh vials.
  • The tertiary amine headgroups (the most reactive part) weren’t even fully analysed for oxidation.

Why does this matter?  Because oxidised lipids are biological grenades. They:

  • Bind to inflammatory receptors (TLRs, PPARs).
  • Disrupt calcium channels and glucose metabolism.
  • Promote vesicle aggregation (think: lysosomes clumping together).

And that’s before we even get to what happens inside your cells.

The Mother of All Bombs Moment

A groundbreaking review, ‘The Chemical Reactivity of Membrane Lipids’, drops the mic: “When primary amines are present in membranes (e.g., sphingosine), reactive aldehydes can crosslink them, triggering vesicle aggregation.”

Translation: The ionisable amines in LNPs (ALC-0315/SM-102) don’t just deliver mRNA – they wreak havoc on membrane integrity.

  • Cholesterol ratios in LNPs? They speed up lipid hydrolysis (i.e., breakdown).
  • Tertiary amines? They bind receptors directly, hijacking cell signalling.

This isn’t just about transfection – it’s about slow, systemic toxicity that flies under the radar of typical safety studies.

The Alarming Implications

  1. Endosomal escape gone wrong: LNPs are designed to escape endosomes, but oxidised/altered lipids might clog lysosomes, disrupting cellular waste disposal.
  2. Receptor chaos: Oxidised lipids bind PPARs, TLRs, and CD14, fuelling inflammation and metabolic dysfunction.
  3. Long-term damage: Hydrolysis and crosslinking could mean progressive cell membrane dysfunction – think neurodegenerative or autoimmune triggers.

The Unanswered Question

Were some vials worse than others? With no batch consistency data, we might never know.

Bottom line: Billions of people have been injected with a poorly characterised chemical delivery system – and now we’re just starting to see the fallout.

What’s Next?

We need transparency from both the vaccine manufacturers and drug regulators. Batch testing, LNP quantification and oxidation studies would be a good start, but we need long-term tracking to understand how long lipids persist in the body, and the extent of cellular damage caused. In the meantime, as ever, World Council for Health continues to call for these dangerous gene therapies to be withdrawn.

All those concerned about toxicity as a result of receiving the mRNA gene therapies can take action to support the body’s healing. Take a look at our ‘Detox & Wellness Guide’ for practical strategies you can take, and consider joining our ‘Detox & Wellbeing Study’.

Rhoda Wilson


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